Models Bella and Gigi Hadid are collectively donating one million dollars (£785,000) to support relief efforts, according to their agent.
The money will go to Heal Palestine, Palestine Children's Relief Fund (PCRF), World Central Kitchen (WCK), and United Nations Relief and Works Agency (UNRWA).
The sisters have frequently been vocal in their support for Gaza, and their father Mohamed Anwar Hadid is himself Palestinian.
After Hamas's 7 October attack on Israel, Gigi, 29, offered her condolences to those affected.
"My thoughts are with all those affected by this unjustifiable tragedy, and every day that innocent lives are taken by this conflict - too many of which are children," she wrote on Instagram.
"I have deep empathy and heartbreak for the Palestinian struggle and life under occupation, it's a responsibility I hold daily."
She added: "While I have hopes and dreams for Palestinians, none of them include the harm of a Jewish person."
Bella, 27, said in May that she was "devastated at the loss of the Palestinian people and the lack of empathy coming from the government systems worldwide".