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| Name | Dr. Johannes Schwab | Molecular Flexibility in Cryo Electron Microscopy |
| Video Uploader | Video From INI Seminar Room 1 |
| Upload Date | This Video Uploaded At 23-05-2023 07:17:38 |
| Video Discription | Speaker(s): Dr Johannes Schwab (MRC Laboratory of Molecular Biology) Date: 18 May 2023 - 16:00 to 17:00 Venue: INI Seminar Room 1 Session Title: Molecular Flexibility in Cryo Electron Microscopy Event: [RNTW03] New tomographic methods using particles Cryogenic electron microscopy (cryo-EM) is a powerful technique to obtain the 3D structure of macromolecules from thousands of noisy projection images. Since these macromolecules are flexible by nature, the areas shows lower resolution and gives a blurry reconstruction. We propose a novel method incorporated in a software package named dynamight, that represents the molecule with gaussian basis functions and estimates deformation fields for every experimental image by a variational autoencoder. We further use the estimated deformations to better resolve the flexible regions in the reconstruction using a filtered backprojection algorithm along curved lines. We present results on real data showing that we obtain improved 3D reconstruction. |
| Category | Education |
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