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| Name | High fried food consumption impacts anxiety and depression due to neuroinflammation | Prof Fontana |
| Video Uploader | Video From Longevity-NOW-FL | Prof Luigi Fontana, MD, PhD |
| Upload Date | This Video Uploaded At 21-05-2023 13:41:36 |
| Video Discription | Western dietary patterns have been unfavorably linked with mental health. A study published in PNAS shows that high intake of fried food may be responsible, at least in part, of the increased risk of anxiety and depression via acrylamide-mediated activation of neuroinflammation. This population-based study with 140,728 people revealed that frequent fried food consumption, especially fried potato consumption, is strongly associated with 12% and 7% higher risk of anxiety and depression, respectively. The associations were more ****ounced among male and younger consumers. Consistently, long-term exposure to acrylamide, a representative food processing contaminant in fried products, exacerbates scototaxis and thigmotaxis, and further impairs exploration ability and sociality of adult zebrafish, showing anxiety- and depressive-like behaviors. Moreover, treatment with acrylamide significantly down-regulates the gene expression of tjp2a related to the permeability of blood–brain barrier. Multiomics analysis showed that chronic exposure to acrylamide induces cerebral lipid metabolism disturbance and neuroinflammation. PPAR signaling pathway mediates acrylamide-induced lipid metabolism disorder in the brain of zebrafish. Especially, chronic exposure to acrylamide dysregulates sphingolipid and phospholipid metabolism, which plays important roles in the development of anxiety and depression symptoms. In addition, acrylamide promotes lipid peroxidation and oxidation stress, which participate in cerebral neuroinflammation. Acrylamide dramatically increases the markers of lipid peroxidation, including (±)5-HETE, 11(S)-HETE, 5-oxoETE, and up-regulates the expression of proinflammatory lipid mediators such as (±)12-HETE and 14(S)-HDHA, indicating elevated cerebral inflammatory status after chronic exposure to acrylamide. https://www.pnas.org/doi/10.1073/pnas.2221097120 Neuroinflammation is also deeply implicated in the pathogenesis of dementia! |
| Category | Education |
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